Acute Respiratory Distress Syndrome

The Tie2-agonist Vasculotide rescues mice from influenza virus infection.

Sugiyama MG, Armstrong SM, Wang C, Hwang D, Leong-Poi H, Advani A, Advani S, Zhang H, Szaszi K, Tabuchi A, Kuebler WM, Van Slyke P, Dumont DJ, Lee WL.
Sci Rep. 2015 Jun 5;5:11030.

The Tie2-Agonist Vasculotide Protects Lungs from Pneumonia-Induced Barrier Disruption.

Gutbier B, Jiang X, Ehrler C, Mitchell TJ, Weissmann N, Van Slyke P, Dumont DJ, Suttorp N, Witzenrath M. American Thoracic Society 2016 International Conference.

Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality.

David S, Ghosh CC, Kümpers P, Shushakova N, Van Slyke P, Khankin EV, Karumanchi SA, Dumont D, Parikh SM. Am J Physiol Lung Cell Mol Physiol. 2011 Jun;300(6):L851-62.

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.

Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Hoang VC, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M.
Crit Care. 2017 Nov 13;21(1):274.

Acute Kidney Injury

The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function In Experimental Acute Kidney Injury.

Rübig E, Stypmann J, Van Slyke P, Dumont DJ, Spieker T, Buscher K, Reuter S, Goerge T, Pavenstädt H, Kümpers P. Sci Rep. 2016 Feb 25;6:22111.

Pharmacological Tie2 activation in kidney transplantation.

Thamm K, Njau F, Van Slyke P, Dumont DJ, Park JK, Haller H, David S.
World J Transplant. 2016 Sep 24;6(3):573-82.

Cardiopulmonary Bypass (CPB)

Vasculotide, an angiopoietin-1 mimetic, reduces pulmonary vascular leakage and preserves microcirculatory perfusion during cardiopulmonary bypass in rats.

Dekker NAM, van Meurs M, van Leeuwen ALI, Hofland HM, van Slyke P, Vonk ABA, Boer C, van den Brom CE. Br J Anaesth. 2018 Nov;121(5):1041-1051. doi: 10.1016/j.bja.2018.05.049. Epub 2018 Jun 19. PMID: 30336848

Hemorrhagic Shock

Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock.

Trieu M, van Meurs M, van Leeuwen ALI, Van Slyke P, Hoang V, Geeraedts LMG Jr, Boer C, van den Brom CE. Anesthesiology. 2017 Sep 29.

Mitigating Microvascular Leak during Fluid Resuscitation of Hemorrhagic Shock.

Walley KR. Anesthesiology. 2017 Dec 12.

Radiation Toxicity

Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model.

Korpela E, Yohan D, Chin LC, Kim A, Huang X, Sade S, Van Slyke P, Dumont DJ, Liu SK.
BMC Cancer. 2014 Aug 26;14:614

Sepsis

Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis

Drost, C.C., Rovas, A., Kusche-Vihrog, K., Van Slyke, P., Kim, H., Hoang, V.C., Maynes, J.T., Wennmann, D.O., Pavenstädt, H., Linke, W. and Lukasz, A., 2019. Thrombosis and haemostasis, 119(11), pp.1827-1838.

The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis.

Kumpers P, Gueler F, David S, Slyke PV, Dumont DJ, Park JK, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H, Shushakova N. Crit Care. 2011;15(5):R261.

Wound Healing

Acceleration of diabetic wound healing by an angiopoietin peptide mimetic.

Van Slyke P, Alami J, Martin D, Kuliszewski M, Leong-Poi H, Sefton MV, Dumont D.
Tissue Eng Part A. 2009 Jun;15(6):1269-80.

Other Indications

Angiopoietin-1 Mimetic Peptide Promotes Neuroprotection after Stroke in Type 1 Diabetic Rats.

Venkat P, Yan T, Chopp M, Zacharek A, Ning R, Van Slyke P, Dumont D, Landschoot-Ward J, Liang L, Chen J. Cell Transplant. 2018 Aug 20:963689718791568. doi: 10.1177/0963689718791568. [Epub ahead of print] PMID: 30124060

Pharmacological Tie2 activation in kidney transplantation.

Thamm K, Njau F, Van Slyke P, Dumont DJ, Park JK, Haller H, David S. World J Transplant. 2016 Sep 24;6(3):573-82. doi: 10.5500/wjt.v6.i3.573. PMID: 27683636

Endothelial Activation: The Ang/Tie Axis in Sepsis.

Leligdowicz A, Richard-Greenblatt M, Wright J, Crowley VM, KainKC.
Front Immunol. 2018Apr 24;9:838. doi: 10.3389/fimmu.2018.00838. eCollection 2018. Review.
PMID: 29740443

Angiopoietins and Tie2 in vascular inflammation.

Parikh SM.
Curr Opin Hematol. 2017Sep;24(5):432-438. doi: 10.1097/MOH.0000000000000361. Review.
PMID: 28582314

Supportive Publications

Acute Respiratory Distress Syndrome.

Thompson BT, Chambers RC, Liu KD.
N Engl J Med. 2017 Aug 10;377(6):562-572. doi: 10.1056/NEJMra1608077. Review. No abstract available. PMID: 28792873

Acute respiratory distress syndrome: the Berlin Definition.

ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS.
JAMA. 2012 Jun 20;307(23):2526-33. doi: 10.1001/jama.2012.5669. PMID: 22797452

Acute Respiratory Distress Syndrome: Advances in Diagnosis and Treatment.

Fan E, Brodie D, Slutsky AS.
JAMA. 2018 Feb 20;319(7):698-710. doi: 10.1001/jama.2017.21907. Review.
PMID: 29466596

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.

Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.
JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291. Erratum in: JAMA. 2016 Jul 19;316(3):350. JAMA. 2016 Jul 19;316(3):350.
PMID: 26903337

Acute Respiratory Distress Syndrome

The Tie2-agonist Vasculotide rescues mice from influenza virus infection.

The Tie2-Agonist Vasculotide Protects Lungs from Pneumonia-Induced Barrier Disruption.

Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality.

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.

Acute Kidney Injury

The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function In Experimental Acute Kidney Injury.

Pharmacological Tie2 activation in kidney transplantation.

Cardiopulmonary Bypass (CPB)

Vasculotide, an angiopoietin-1 mimetic, reduces pulmonary vascular leakage and preserves microcirculatory perfusion during cardiopulmonary bypass in rats.

Hemorrhagic Shock

Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock.

Mitigating Microvascular Leak during Fluid Resuscitation of Hemorrhagic Shock.

Radiation Toxicity

Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model.

Sepsis

Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis

The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis.

Wound Healing

Acceleration of diabetic wound healing by an angiopoietin peptide mimetic.

Other Indications

Angiopoietin-1 Mimetic Peptide Promotes Neuroprotection after Stroke in Type 1 Diabetic Rats.

Pharmacological Tie2 activation in kidney transplantation.

Endothelial Activation: The Ang/Tie Axis in Sepsis.

Angiopoietins and Tie2 in vascular inflammation.

Supportive Publications

Acute Respiratory Distress Syndrome.

Acute respiratory distress syndrome: the Berlin Definition.

Acute Respiratory Distress Syndrome: Advances in Diagnosis and Treatment.

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.

Lessons to learn from epidemiologic studies in ARDS.

Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care.

The ten studies that should be done in ARDS.

Influenza lung injury: mechanisms and therapeutic opportunities.

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