AV-001 Receives Positive Recommendation from the IDSMB for AV001-004 Phase 2a Study
Vasomune and AnGes Announce Drug Candidate AV-001 Receives Positive Recommendation from the IDSMB for AV001-004 Phase 2a Study
Vasomune Therapeutics is a private biotechnology company developing the next generation of medications to harness the body’s ability to defend against illness by modifying the host vascular endothelial response to disease.
The company’s drug candidate AV-001 targets a signaling molecule in the vasculature responsible for regulating barrier defense and the host vascular response to injury. In response to injury or infection, the host vascular response can become unconstrained driving impairment of lung function, edema in critical organs, and fluid loss that leads to organ dysfunction and death. AV-001 activates Tie2, a tyrosine kinase receptor expressed on the cell surface of endothelial cells in the vasculature. Activated Tie2 is important for maintaining vascular homeostasis which promotes barrier defense against vascular leakage, and counteracts vascular inflammation.
Published studies of AV-001 or its predecessor analog Vasculotide, have demonstrated efficacy in multiple preclinical models, including reduction of vascular dysfunction in trauma and pathogen-induced disease models. Vascular dysfunction is a foundational mechanism for multiple additional disease states such as:
Vasomune is initially developing AV-001 for the treatment of patients with pathogen-induced Acute Respiratory Distress Syndrome (ARDS).
AV-001, a synthetic Angiopoietin 1 mimetic, activates the Tie2 receptor which is highly expressed on the surface of endothelial cells located within the vasculature.. AV-001 is designed to interact with the Tie2 receptor on a binding domain distinct from the natural ligands Angiopoietin 1 and Angiopoietin 2.
Activation of Tie2 broadly promotes barrier defense against vascular leak and counteracts vascular inflammation by decreasing the activity of multiple pro-inflammatory factors. AV-001 represents a novel multifactorial approach that acts at the cellular and tissue-level. This approach is in contrast to the traditional highly specific lock and key therapies aimed at killing the pathogen or individual targets within the inflammatory response pathway. There are no clinically available medications to treat vascular leak.
Vasomune and AnGes Announce Drug Candidate AV-001 Receives Positive Recommendation from the IDSMB for AV001-004 Phase 2a Study
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First subjects have been dosed in Phase 1 study of AV-001, a novel first-in-class therapeutic Should the Phase 1 results show AV-001 is safe and
Vasomune Therapeutics is a private biotechnology company developing the next generation of medications to harness the body’s ability to defend against illness by modifying the host vascular endothelial response.