Developing novel therapies to treat vascular leak


Vasomune, its scientific founders, advisors and collaborators have published and presented their research findings related to Vasculotide internationally.


Below are some recent publications that describe Vasculotide and its therapeutic applications:


Lung Injury

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.

Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Hoang VC, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M.

Crit Care. 2017 Nov 13;21(1):274.


The Tie2-agonist Vasculotide rescues mice from influenza virus infection.

Sugiyama MG, Armstrong SM, Wang C, Hwang D, Leong-Poi H, Advani A, Advani S, Zhang H, Szaszi K, Tabuchi A, Kuebler WM, Van Slyke P, Dumont DJ, Lee WL.

Sci Rep. 2015 Jun 5;5:11030.


The Tie2-Agonist Vasculotide Protects Lungs from Pneumonia-Induced Barrier Disruption.

Gutbier B, Jiang X, Ehrler C, Mitchell TJ, Weissmann N, Van Slyke P, Dumont DJ, Suttorp N, Witzenrath M.  American Thoracic Society 2016 International Conference.


Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality.

David S, Ghosh CC, Kümpers P, Shushakova N, Van Slyke P, Khankin EV, Karumanchi SA, Dumont D, Parikh SM. Am J Physiol Lung Cell Mol Physiol. 2011 Jun;300(6):L851-62.



Kidney Injury


The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function In Experimental Acute Kidney Injury.
Rübig E, Stypmann J, Van Slyke P, Dumont DJ, Spieker T, Buscher K, Reuter S, Goerge T, Pavenstädt H, Kümpers P. Sci Rep. 2016 Feb 25;6:22111.


Pharmacological Tie2 activation in kidney transplantation.

Thamm K, Njau F, Van Slyke P, Dumont DJ, Park JK, Haller H, David S.

World J Transplant. 2016 Sep 24;6(3):573-82.



Hemorrhagic Shock


Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock. Trieu M, van Meurs M, van Leeuwen ALI, Van Slyke P, Hoang V, Geeraedts LMG Jr, Boer C, van den Brom CE. Anesthesiology. 2017 Sep 29.


Mitigating Microvascular Leak during Fluid Resuscitation of Hemorrhagic Shock.

Walley KR. Anesthesiology. 2017 Dec 12.



Radiation Toxicity


Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model.  Korpela E, Yohan D, Chin LC, Kim A, Huang X, Sade S, Van Slyke P, Dumont DJ, Liu SK.

BMC Cancer. 2014 Aug 26;14:614





The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Kumpers P, Gueler F, David S, Slyke PV, Dumont DJ, Park JK, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H, Shushakova N. Crit Care. 2011;15(5):R261.



Wound Healing


Acceleration of diabetic wound healing by an angiopoietin peptide mimetic. Van Slyke P, Alami J, Martin D, Kuliszewski M, Leong-Poi H, Sefton MV, Dumont D. Tissue Eng Part A. 2009 Jun;15(6):1269-80.

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